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The trial tested whether tadalafil increases brain blood flow in older men and women with narrowing of the brain arteries, a condition that can cause strokes and vascular dementia.
Although the trial results found no significant increase in blood flow, the researchers found clues pointing towards a potential use for tadalafil in treating certain groups of patients, warranting further investigation. Dementia is an escalating global healthcare challenge, estimated to affect 55 million people worldwide, increasing to million by There are few treatment options for patients, and the new trial explored whether repurposing an existing drug, tadalafil, may have potential for treating vascular dementia — a common type of dementia in which there is reduced blood flow to the brain.
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Tadalafil belongs to the same group of drugs, and the researchers hypothesize that the mechanisms that increase blood flow in other parts of the body, may also apply in the brain — providing brain cells with a healthier blood supply and reducing dementia symptoms.
Tadalafil was selected as the drug candidate for the trial because of its longer half-life remaining in the bloodstream for longer and evidence that it is better able to enter the brain, than its related drugs.
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The trial compared a single dose of tadalafil with placebo, recording brain blood flow using an MRI-based method called arterial spin labelling, which traces blood flow without the need for radioactive tracers. The investigators did not detect a significant difference in blood flow between those given tadalafil and those given a placebo.
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However, the results did show a trend for increased blood flow in older participants those aged over 70 in the white matter of the brain, which is the area most important for vascular dementia. The research team believe further investigation of tadalafil should be considered to explore its effectiveness in older age groups over a longer time period.
This was a landmark study in which we attempted to reverse the reduction in brain blood flow characteristic of this condition. Repurposed drugs have the increased benefits of a shorter development time, a known safety profile and low cost, once their original patent has expired.
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We hope that further investigations will prove fruitful and provide new options for clinicians treating dementia. Using existing medications, such as Viagra-like drugs, could shave decades off our search for treatments because they are already shown to be safe for people to use.
These are outlined in the supplementary information of the paper. Home News Viagra-like drugs may play role in treating dementia. No serious adverse events were recorded during the trial.
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